VK-28

SKU: orb1297775

Description

VK-28 is a brain-penetrant iron chelator that provides neuroprotection by inhibiting both basal and iron-induced mitochondrial lipid peroxidation. It is a research tool for studying iron-mediated oxidative stress in neurodegenerative models, such as Parkinson's disease, in both cellular and animal studies.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 312611-92-0
• MW: 287.36
• Purity: 99.87%
• Formula: C₁₆H₂₁N₃O₂
• SMILES: C(C=1C2=C(C(O)=CC1)N=CC=C2)N3CCN(CCO)CC3
• Target: Ferroptosis,Mitochondrial Metabolism,Lipid
• Solubility: DMSO:45 mg/mL (156.6 mM)

Bioactivity

• In Vivo:
  VK-28(1 microg; i.c.v.) was able to completely protect against ICV 6-OHDA (250 microg) induced striatal dopaminergic lesion, as measured by dopamine (DA), dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA) levels. VK-28 (1 and 5 mg/kg; i.p.) daily for 10 and 7 days, respectively, demonstrated significant neuroprotection against ICV 6-OHDA at the higher dose, with 68% protection against loss of dopamine at 5mg/kg dosage of VK-28.
• In Vitro:
  VK-28 inhibited both basal and Fe/ascorbate induced mitochondrial membrane lipid peroxidation, with an IC50 of 12.7 microM comparable to that of the prototype iron chelator, desferal, which does not cross the blood brain barrier.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lipid, iron chelator, MitochondrialMetabolism, Mitochondrial Metabolism, Mitochondria, VK 28, VK28, VK-28

Compound Identifiers

PubChem CID

4490594