VK-1727

SKU: orb2278525

Description

VK-1727 is a selective EBNA1 inhibitor that suppresses EBV-positive cell proliferation and metabolism by blocking EBNA1-DNA binding, showing specificity by sparing EBV-negative cells. It is a key research tool for investigating EBNA1's role in diseases like multiple sclerosis, with utility in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Molecular Biology

Key Properties

• MW: 451.51
• Formula: C₂₉H₂₅NO₄
• SMILES: COC(C1=CC=CC(C#CC(C=C2)=CC=C2OC3CCOCC3)=C1C4=CC=C(C=CN5)C5=C4)=O
• Target: Others
• Solubility: DMSO:80 mg/mL (177.18 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.31 mM)

Bioactivity

• In Vitro:
  Methods: EBV+ cells were treated with VK-1727 (25 μM, 72 hours), and the cell cycle was analyzed by flow cytometry. Results: VK-1727 significantly reduced the total number of G2-phase cells in EBV+ cells (HC1-2, SMS1-3, and AMS1-4), while no similar effect was observed in EBV− cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VK1727

Quick Database Links

Gene Symbol

Others