Vitamin K

SKU: orb1940598

Description

Vitamin K has blood coagulation action and is important for coagulation factors, matrix-Gla protein, and osteocalcin.(In Vitro):Vitamin K plays an important role in nervous system. Vitamin K facilitates the bioactivation of protein Gas6 and protein S, ligands of the TAM family (Tyro3, Axl and Mer) receptor tyrosine kinases. In the brain, vitamin K is involved in the synthesis of sphingolipids .(In Vivo):Vitamin K supplementation is beneficial in improving insulin sensitivity and glucose tolerance, reducing the risk of type 2 diabetes, and preventing insulin resistance. The recommended intake of adequate vitamin K is 90 micrograms per day for women and 120 micrograms per day for men . Vitamin K deficiency leads to an increase in hypocarboxylated osteocalcin, a decrease in bone mineral density, and an increased probability of fracture. Vitamin K supplementation reduces undercarboxylated osteocalcin and improves bone turnover curves .

Key Properties

• CAS Number: 12001-79-5
• MW: ——
• Purity: >98% (HPLC)
• Formula: ——
• Target: Endogenous Metabolite
• Solubility: In Vitro: DMSO : 50 mg/mL

Bioactivity

• In Vivo:
  Vitamin K is well-known for its function in blood coagulation. Several human studies report the beneficial role of vitamin K supplementation in improving insulin sensitivity and glucose tolerance, preventing insulin resistance, and reducing the risk of type 2 diabetes. The adequate intake for vitamin K has been proposed to be 90 μg/day for women and 120 μg/day for men. Vitamin K deficiency results in an increase in undercarboxylated osteocalcin, a protein with low biological activity. Several studies have demonstrated that low dietary vitamin K intake is associated with low bone mineral density or increased fractures. Additionally, vitamin K supplementation has been shown to reduce undercarboxylated osteocalcin and improve the bone turnover profile.
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• In Vitro:
  Phylloquinone (vitamin K1) and Menaquinones (vitamin K2) are the two naturally occurring forms of vitamin K. Phylloquionone is the major dietary source of vitamin K and is found at highest concentrations in green leafy vegetables. Vitamin K2 (menaquinone) is found in small amounts in chicken, butter, egg yolks, cheese and fermented soyabeans. Vitamin K1 and vitamin K2 are required for the γ-glutamyl carboxylation of all vitamin K-dependent proteins. Vitamin K has important actions in the nervous system. Vitamin K contributes to the biological activation of proteins Gas6 and protein S, ligands for the receptor tyrosine kinases of the TAM family (Tyro3, Axl, and Mer). In brain, vitamin K also participates in the synthesis of sphingolipids, an important class of lipids present in high concentrations in brain cell membranes.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Kephton | Vitamin K1(20)

Quick Database Links

Gene Symbol

Endogenous Metabolite