Vitamin E succinate

SKU: orb2900716

Description

D-α-Tocopherol Succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E. D-α-Tocopherol Succinate inhibits Cisplatin (HY-17394)-induced cytotoxicity. D-α-Tocopherol Succinate can be used for the research of cancer.

Key Properties

• CAS Number: 4345-03-3
• MW: 530.78
• Purity: >98% (HPLC)
• Formula: C₃₃H₅₄O₅
• SMILES: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1
• Target: Apoptosis
• Solubility: In Vitro: DMSO : 250 mg/mL (471.00 mM; Ultrasonic )

Bioactivity

• In Vivo:
  D-α-Tocopherol Succinate (1-2 mg/kg; i.p. three times at 2 day intervals from TC-1 tumor cells injection for 10 days to 14 days) shows antitumor effects to mice with TC-1 tumor. Animal model: Six-to eight-week-old female C57BL/6 mice with TC-1 tumor cells. Dosage: 1 and 2 mg/kg. Administration: Intraperitoneal injection; 1 and 2 mg/kg three times at 2 day intervals; from TC-1 tumor cells injection for 10 days to 14 days. Result: Dreased the tumor volume, especially with a dose of 2 mg/kg.
• In Vitro:
  D-α-Tocopherol Succinate (1-20 μM; 24 hours) shows cytotoxicity to HEI-OC1 cells. D-α-Tocopherol Succinate (10 μM; 48 hours) protects HEI-OC1 cells against cisplatin-induced ototoxicity and inhibits caspase-3 activity. D-α-Tocopherol Succinate (0-50 μM; 18 hours) shows cytotoxicity to TC-1 tumor cells. Cell Cytotoxicity Assay Cell line: HEI-OC1 cell line. Concentration: 1-20 μM. Incubation time: 24 hours. Result: Significantly induced cytotoxicity at a concentration of 20 μM and showed a higher cytotoxicity potency compared with 10 μM. Cell Viability Assay Cell line: HEI-OC1 cell line. Concentration: 10 μM. Incubation time: 48 hours. Result: Increased cisplatin-induced cell population. Inhibited cisplatin-induced necrotic, ROS production and late apoptosis. Decreased cleaved PARP and inhibited the expression of caspase-3 which related to cisplatin-induced apoptosis. Cell Cytotoxicity Assay Cell line: TC-1 tumor cells. Concentration: 0, 25 and 50 μM. Incubation time: 18 hours. Result: Dose-dependently showed cytotoxic and induced a higher percentage of necrotic TC-1 cells as opposed to apoptotic cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis