α-Vitamin E

SKU: orb1307904

Description

Dexrabeprazole Sodium is a research-grade small molecule. As the naturally-occurring α-form of vitamin E, it is a fat-soluble antioxidant used in studies investigating oxidative stress, cellular protection, and lipid metabolism in both in vitro and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 59-02-9
• MW: 430.71
• Purity: 99.89% (May vary between batches)
• Formula: C₂₉H₅₀O₂
• SMILES: CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C(O)=C1C
• Target: PKC,Antibacterial,Reactive Oxygen Species,ROS,Ferroptosis,Endogenous Metabolite,Influenza Virus,GST
• Solubility: Saline:25 mg/mL (58.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1.2 mg/mL (2.79 mM);DMSO:262.5 mg/mL (609.46 mM)

Bioactivity

• Target IC50:
  MT-4 cells:165 μM|U-937 cells:100 μM|MCF-7 cells:> 300 μM|HL-60 cells:255 μM|RPMI8226 cells:> 300 μM|THP-1 cells:> 500 μM|HepG2 cells:> 300 μM|ERα (mouse):> 500 nM (EC50)|Erythrocyte:3.658 μg/mL|J774 cells:> 500 μM
• In Vivo:
  Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation.
• In Vitro:
  vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide.
• Cell Research:
  For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I. (Only for Reference)

Storage & Handling

• Storage: keep away from direct sunlight,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D-alpha-Tocopherol, D-a-Tocopherol, D-α-Tocopherol, (+)-alpha-Tocopherol, 5,7,8-Trimethyltocol, Alpha-Tocopherol, alpha-Vitamin E, a-Tocopherol, a-Vitamin E, Bacterial, Influenza Virus, InfluenzaVirus, GSTP, GST Mu 3, GST omega-1, Ferroptosis, Endogenous Metabolite, EndogenousMetabolite, SEC14-like protein, peroxyl, radical, ReactiveOxygenSpecies, Reactive Oxygen Species, PKC, scavenger, Vitamin E, VE, α-Tocopherol, αVitamin E, α-Vitamin E, α Vitamin E

Compound Identifiers

PubChem CID

14985