VIP236

SKU: orb2664586

Description

VIP236 is a small molecule drug conjugate (SMDC) designed for targeted cancer therapy. It selectively binds to αvβ3 integrin on tumor cells and, upon cleavage by neutrophil elastase in the tumor microenvironment, releases a potent TOP1 inhibitor payload. This mechanism enables precise drug delivery and has demonstrated antitumor efficacy in preclinical in vivo models.

Key Properties

• CAS Number: 2418533-90-9
• MW: 1515.55
• Formula: C₇₂H₈₄N₁₂Na₂O₂₀S
• SMILES: O=C1N2C(C3=NC4=CC=CC=C4C(CC)=C3C2)=CC5=C1COC([C@@]5(CC)OC([C@H](C(C)C)NC([C@H]6N(CCC6)C([C@H](CC([O-])=O)NC(CCOCCOCCOCCNC(NC7=CC=C(C=C7)NC(N[C@@H](C8=CC(NS(=O)(C9=CC(NC(NCCC)=O)=CC=C9)=O)=CC=C8)CC([O-])=O)=O)=O)=O)=O)=O)=O)=O.[Na+].[Na+]

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

156903273