Vinpocetine

SKU: orb1310877

Description

Vinpocetine (RGH-4405) is a synthetic derivative of vincamine that selectively inhibits cyclic GMP phosphodiesterase (PDE). It is widely used in neuroscience research, particularly in in vitro and in vivo studies investigating cerebral blood flow, neuroprotection, and cognitive function.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 42971-09-5
• MW: 350.45
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₂₆N₂O₂
• SMILES: CCOC(=O)C1=CC2(CC)CCCN3CCC4=C(C23)N1C1=C4C=CC=C1
• Target: IκB/IKK,Sodium Channel,NF-κB,PDE
• Solubility: Ethanol:17.5 mg/mL (49.94 mM);DMSO:3.51 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  IKK:17.17 μM|PDE1:21 μM

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IKK, IkB/IKK, IkB, Inhibitor, I kappa B kinase, Ethyl apovincaminate, inhibit, IκB kinase, IκB, Na+ channels, Na channels, PDE, NF-κB, NFkB, NFκB, NF-kB, SodiumChannel, RGH 4405, RGH4405, RGH-4405, Sodium Channel, phosphodiesterase, Phosphodiesterase (PDE), Vinpocetine

Compound Identifiers

PubChem CID

5673