Vinblastine sulfate

SKU: orb1307836

Description

Vinblastine sulfate

Research Area

Cell Biology, Neuroscience, Signal Transduction

Key Properties

• CAS Number: 143-67-9
• MW: 909.06
• Purity: 99.82%
• Formula: C₄₆H₅₈N₄O₉·H₂SO₄
• SMILES: OS(O)(=O)=O.CC[C@]1(O)C[C@H]2C[N@](C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
• Target: Autophagy,Microtubule Associated,AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.5 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:242 mg/mL (266.21 mM)

Bioactivity

• Target IC50:
  nAChR:8.9 μM
• In Vivo:
  Vinblastine, a widely used anticancer drug, has undesired side effects . A combination of VBL and RAP at very low doses achieves a satisfactory antiangiogenic effect against human HCC in vivo . The clinically relevant dose of vinblastine inhibits tubulin palmitoylation in CEM cells (effect on depalmitoylation of tubulin) in vivo .
• In Vitro:
  The average terminal half-lives of Vinblastine is 14.3 h. When incubated in freshly isolated rat hepatocytes, VLB penetrates rapidly and intensely into the cells, probably through a passive diffusion mechanism followed by tight cellular binding. Vinblastine inhibits the angiogenic response induced by adrenomedullin and is also positive for mitotic slippage, causing micronuclei in mononucleate cells with cytokinesis block. vinblastine gives significant increase in micronucleated mononucleated cells at concentrations that produced approximately 50% cell death and cytostasis or less as calculated using RPD, RICC and RCC.
• Cell Research:
  Six-well treatment plates are set up that contained 5 × 104 cells/mL in each well, suspended in 3 mL culture medium, and these are treated with vinblastine for 3 h followed by 21 h growth. (Only for Reference)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Vincaleukoblastine, Vincaleukoblastine Sulfate, Vincaleukoblastine sulfate salt, Vinblastine, Vinblastine sulfate, Vinblastine Sulfate, Autophagy, Microtubule/Tubulin, Microtubule Associated, MicrotubuleAssociated, NSC49842, NSC-49842, nAChR, NSC 49842, inhibit, Inhibitor

Compound Identifiers

PubChem CID

241902