Vimseltinib

SKU: orb1309886

Description

Vimseltinib (DCC-3014) is a potent small molecule inhibitor targeting c-FMS (CSF-1R) and c-Kit with IC50 values of <0.01 μM and 0.1-1 μM, respectively. It is utilized in research exploring tumor-associated macrophages and has demonstrated activity in both in vitro cellular assays and in vivo models of tenosynovial giant cell tumor.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1628606-05-2
• MW: 431.49
• Purity: 99.57% (May vary between batches)
• Formula: C₂₃H₂₅N₇O₂
• SMILES: CC(C)Nc1ncc(-c2ccc(Oc3ccnc(c3)-c3cnn(C)c3)c(C)n2)c(=O)n1C
• Target: c-Fms,c-Kit,CSF-1R
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.65 mM);DMSO:60 mg/mL (139.05 mM)

Bioactivity

• Target IC50:
  c-Kit:0.1-1 μM |c-Fms:<0.01 μM
• In Vitro:
  DCC-3014 has anti-cancer and anti-proliferative activities.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, DCC 3014, DCC3014, DCC-3014, Inhibitor, colony stimulating factor 1 receptor, CD117, cFms, c-Fms, c-FMS/CSF-IR, c-Kit, cKit, CSF-1 receptor, CSF1R, CSF-1R, Vimseltinib, SCFR

Compound Identifiers

PubChem CID

86267612