Vicriviroc maleate

SKU: orb1304205

Description

Vicriviroc maleate is a potent piperazine-based CCR5 antagonist developed for HIV-1 treatment, demonstrating an IC50 of 0.91 nM. It has been investigated in clinical trials and is a valuable research tool for studying CCR5-mediated viral entry in both cellular and animal models of HIV infection.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 599179-03-0
• MW: 649.7
• Purity: 98.16%
• Formula: C₃₂H₄₂F₃N₅O₆
• SMILES: OC(=O)\C=C/C(O)=O.COC[C@H](N1CCN(C[C@@H]1C)C1(C)CCN(CC1)C(=O)c1c(C)ncnc1C)c1ccc(cc1)C(F)(F)F
• Target: CCR,HIV Protease
• Solubility: H2O:25 mg/mL (38.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.08 mM);DMSO:50 mg/mL (76.96 mM)

Bioactivity

• Target IC50:
  HIV-1 (ADA-M):2.8 nM (IC90, in PBMC cells)|HIV-1 (JV1083):4.9 nM (IC90, in PBMC cells)|HIV-1 (JrFL):3.3 nM (IC90, in PBMC cells)|CCR5 receptor:0.91 nM|CCR5 receptor:2.5 nM (Ki)|HIV-1 (RU 570):10 nM (IC90, in PBMC cells)|HIV-1 (301657):1.8 nM (IC90, in PBMC cells)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, HIV, HIV Protease, HIVProtease, Inhibitor, Human immunodeficiency virus, CCR, CC chemokine receptor, CCR5, SCH417690, SCH-417690, SCH-417690 (maleate), SCH-D, SCH-D (maleate), SCH 417690, Vicriviroc, Vicriviroc Maleate, Vicriviroc maleate

Compound Identifiers

PubChem CID

6451165