VI 16832

SKU: orb1706479

Description

VI 16832 is a broad-spectrum Type I kinase inhibitor used as a chemical proteomics tool to profile relative kinase expression across cancer cell lines via quantitative mass spectrometry. Its application facilitates kinase signaling studies and pharmacological research in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1430218-51-1
• MW: 391.47
• Purity: 99.09% (May vary between batches)
• Formula: C₂₂H₂₅N₅O₂
• SMILES: O=C1C=CC=2C=NC(=NC2N1C3CC4CCC3C4)NC5=CC=C(OCCN)C=C5
• Target: Syk,Others,Src
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (5.11 mM);DMSO:24 mg/mL (61.31 mM)

Bioactivity

• In Vitro:
  VI 16832 is a broad-spectrum type I kinase inhibitor . Phosphoproteomic analysis of VI 16832-enriched fractions in MV4-11, HCT116, or 435S cells identified over 8,500 phosphopeptides. These phosphopeptides correspond to 212 distinct members of the protein kinase superfamily, forming nearly 1,700 different phosphopeptide species. Analysis of VI 16832-bound retained proteins across the three cancer cell lines significantly increased the total number of identified phosphorylation sites on protein kinases. When the sum of all phosphopeptide intensities was used as a measure of VI 16832-enriched protein quantity, it was found that over 80% of these proteins originated from protein kinases .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Type I kinase, VI 16832, VI16832, VI-16832

Compound Identifiers

PubChem CID

89510076