Vesnarinone

SKU: orb1304177

Description

Vesnarinone (Arkin, INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier exhibiting dose-dependent positive inotropic effects with minimal heart rate reduction. Its research applications extend to studying p53-mediated cell cycle arrest, as it induces p21 expression to suppress proliferation and promote apoptosis in vitro.

Research Area

Infectious Disease & Virology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 81840-15-5
• MW: 395.45
• Purity: 98.75% (May vary between batches)
• Formula: C₂₂H₂₅N₃O₄
• SMILES: COc1ccc(cc1OC)C(=O)N1CCN(CC1)c1ccc2NC(=O)CCc2c1
• Target: PDE,HIV Protease
• Solubility: DMSO:3.96 mg/mL (10.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.53 mM)

Bioactivity

• Target IC50:
  PDE3:1.1 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

heart failure, HIV Protease, HIV, HIVProtease, Inhibitor, inhibit, PDE, OPC8212, OPC-8212, OPC 8212, oral activity, OSC3, OSC4, OSC5, Arkin, phosphodiesterase 3, Phosphodiesterase (PDE), phosphodiesterase, positive inotropic activity, Piteranometozine, Vesnarinone

Compound Identifiers

PubChem CID

5663