Verrucarin A

SKU: orb1690043

Description

Verrucarin A is a macrocyclic mycotoxin and protein synthesis inhibitor derived from Myrothecium verrucaria. It exhibits potent anti-leukemic activity in vitro by inducing apoptosis, modulating p38/ERK/Akt signaling, and deregulating the cell cycle via p53/p21. Its effects on inflammatory pathways in macrophages make it a compound of interest for oncology and immunology research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 3148-09-2
• MW: 502.55
• Formula: C₂₇H₃₄O₉
• SMILES: CC12[C@@]3([C@@]4(O[C@]5([C@]1(COC(=O)[C@@H](O)[C@H](C)CCOC(=O)\C=C\C=C\C(=O)O[C@@]2(C4)[H])CCC(C)=C5)[H])[H])CO3
• Target: ROS,Reactive Oxygen Species,Apoptosis,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

176418398

Kanhaya Lal et al. Molecular Dynamics and Quantum Chemical Insights into the Molecular Basis of Differential Toxicity of the Mycotoxin Deoxynivalenol (DON) and Its Microbial Derivatives DOM-1 and 3-epi-DON ACS Omega, (2026)

PubMed: