Verinurad

SKU: orb1226470

Description

A highly potent and specific URAT1 inhibitor with IC50 of 25 nM; displays 200-fold lower affinity for the related URAT1 homologs OAT4 and OAT1; reduces the sUA by up to 60% with a single 40 mg dose in healthy human volunteers, and increases the FEUA in a dose-dependent manner with EC50 of 22 nM; currently in phase 2 trials for the treatment of gout and asymptomatic hyperuricemia.Gout Phase 2 Clinical(In Vitro):Verinurad inhibits the transport activity of human URAT1 in a dose-dependent manner, at high potency with an IC50 of 25 nM.

Key Properties

• CAS Number: 1352792-74-5
• MW: 348.4182
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆N₂O₂S
• SMILES: CC(C)(SC1=C(C2=C3C=CC=CC3=C(C#N)C=C2)C=NC=C1)C(O)=O
• Target: URAT1
• Solubility: 10 mM in DMSO

Bioactivity

• In Vitro:
  Verinurad inhibits the transport activity of human URAT1 in a dose-dependent manner, at high potency with an IC50 of 25 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RDEA-3170

Quick Database Links

Gene Symbol

URAT1