Verdiperstat

SKU: orb1301770

Description

Verdiperstat (AZD3241) is an orally bioavailable, irreversible, and selective myeloperoxidase inhibitor with an IC50 of 630 nM. It has been investigated in preclinical models for neurodegenerative diseases like Parkinson's and Alzheimer's, where MPO-mediated oxidative stress is implicated in pathology.

Research Area

Metabolism Research

Key Properties

• CAS Number: 890655-80-8
• MW: 253.32
• Purity: 99.36%
• Formula: C₁₁H₁₅N₃O₂S
• SMILES: CC(C)OCCn1c2cc[nH]c2c(=O)[nH]c1=S
• Target: Glutathione Peroxidase
• Solubility: DMSO:150 mg/mL (592.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.79 mM)

Bioactivity

• Target IC50:
  Myeloperoxidase:630 nM
• In Vitro:
  Verdiperstat (AZD3241) functions as a myeloperoxidase (MPO) inhibitor, demonstrating potency with an IC50 value of 630 nM. It is primarily utilized in the study of neurodegenerative brain disorders. By selectively and irreversibly targeting MPO, Verdiperstat (AZD3241) potentially reduces oxidative stress, consequently diminishing prolonged neuroinflammation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AZD 3241, AZD3241, AZD-3241, myeloperoxidase, inhibit, Inhibitor, GlutathionePeroxidase, Glutathione Peroxidase, Verdiperstat

Compound Identifiers

PubChem CID

11528958