VER-50589

SKU: orb1305877

Description

VER-50589

Research Area

Cell Biology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 747413-08-7
• MW: 388.8
• Purity: 99.96%
• Formula: C₁₉H₁₇ClN₂O₅
• SMILES: CCNC(=O)c1noc(c1-c1ccc(OC)cc1)-c1cc(Cl)c(O)cc1O
• Target: Apoptosis,HSP
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:71 mg/mL (182.61 mM);DMSO:71 mg/mL (182.61 mM)

Bioactivity

• Target IC50:
  HSP90 β:21 nM
• In Vivo:
  The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro.
• In Vitro:
  The induction of HSP72 and HSP27 by VER-50589 was accompanied by depletion of client proteins (including C-RAF, B-RAF, and survivin) and the protein arginine methyltransferase PRMT5, which further led to cell cycle arrest and apoptosis.VER-50589 inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 with an IC50 of 143 nM, and inhibited the intrinsic ATPase activity of recombinant yeast Hsp90 in vitro with an IC50 of 143 nM. and produced antiproliferative activity in a panel of human cancer cell lines and non-tumorigenic cells in vitro.
• Cell Research:
  Antiproliferative effects are measured using the sulforhodamine B assay. HUVEC sensitivity is determined by an alkaline phosphatase method.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, HSP, Heat shock proteins, Inhibitor, HSP90β, inhibit, VER 50589, VER50589, VER-50589

Compound Identifiers

PubChem CID

135446210