Veliparib dihydrochloride

SKU: orb1223672

Description

Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively; displays no activity against SIRT2 and selective biochemical profile in a panel of 74 receptor-binding assays; strongly potentiates temozolomide in the B16F10 s.c. murine melanoma model, also potentiates temozolomide, platinums, cyclophosphamide, and radiation in syngeneic and xenograft tumor models. Breast Cancer Phase 3 Clinical.

Key Properties

• CAS Number: 912445-05-7
• MW: 317.2142
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₈Cl₂N₄O
• SMILES: C[C@@]1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N.Cl.Cl
• Target: PARP
• Solubility: DMSO: ≥ 3.2 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABT-888 dihydrochloride | ABT888 dihydrochloride | ABT 888 dihydrochloride

Quick Database Links

Gene Symbol

PARP