VEGFR2-IN-84

SKU: orb3211308

Description

VEGFR2-IN-84 is an orally active, multi-target tyrosine kinase inhibitor with a naphthalene-based structure. It inhibits VEGFR2 with sub-nanomolar affinity and targets kinases such as Kit, FGFR, PDGFR, and Ret. VEGFR2-IN-84 competitively binds to the ATP binding pocket, blocking the phosphorylation of VEGFR2 and its downstream AKT/ERK signaling pathways. This significantly inhibits endothelial cell proliferation, migration, and tumor angiogenesis. It exhibits broad-spectrum antiproliferative activity against various solid tumors including liver, lung, and kidney cancers, with minimal cytotoxicity to normal cells, outperforming Lenvatinib. VEGFR2-IN-84 has favorable pharmacokinetic properties and high safety (LD50>2000 mg/kg), making it suitable for research on various malignant tumors.

Key Properties

• CAS Number: 861877-12-5
• MW: 470.50
• Formula: C₂₅H₁₈N₄O₄S
• SMILES: O=C(N)C1=CC=2C(=NC=CC2OC3=CC=C4C(C=CC=C4C(=O)NC5=NC=CS5)=C3)C=C1OC
• Target: FGFR,PDGFR,Akt,FLT,ERK,VEGFR,c-Kit,c-RET

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

FGFR,PDGFR,Akt,FLT,ERK,VEGFR,c-Kit,c-RET