VEGFR2-IN-1

SKU: orb1688139

Description

VEGFR2-IN-1 is a selective and potent inhibitor of VEGFR2 kinase. It demonstrates antitumor activity by suppressing cellular proliferation and migration in breast cancer research models, applicable for both in vitro and in vivo experimental studies.

Research Area

Cardiovascular Research, Cardiovascular Research; Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2765224-55-1
• MW: 398.48
• Purity: 98.65% (May vary between batches)
• Formula: C₂₂H₁₈N₆S
• SMILES: N(=C/C=1C=2C(NC1)=CC=CC2)\N3C(=NN=C3SCC=C)C4=CC=5C(N4)=CC=CC5
• Target: VEGFR

Bioactivity

• Target IC50:
  MCF-7 cells:1.18 μM|VEGFR2:19.8 nM|1.18 μM:MDA - MB - 231|MCF - 10A:24.76 μM
• In Vivo:
  In Male Swiss albino mice, 21-28 g ( Xenograft model )，VEGFR2-IN-1 ( 4.2 mg/kg; i.p.; once a days ; 7 days ) Showed anticancer activity by having a tumor inhibition ratio of 54.2 % .
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• In Vitro:
  VEGFR2-IN-1 ( 0.1,1,10,100μM ; 48 h ) were effective selective inhibitors of Mcf-7, Mda-Mb-231 and Mcf-10A : MCF-7 ( IC50 = 1.18 μM ), MDA-MB-231 ( IC50 = 10.49 μM ), MCF-10A ( IC50 = 24.76 μM ).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VEGFR2

Compound Identifiers

PubChem CID

163196457