VEGFR-2/BRAF-IN-1

SKU: orb1744794

Description

VEGFR-2/BRAF-IN-1 is a potent dual kinase inhibitor targeting VEGFR-2 and both wild-type and V600E mutant BRAF, with IC50 values in the nanomolar range. It induces apoptosis and G1/S phase cell cycle arrest, supporting its use in cancer research for in vitro mechanistic studies and in vivo models of angiogenesis and tumor growth.

Research Area

Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction

Key Properties

• MW: 642.5
• Formula: C₂₆H₂₀Cl₂F₃N₅O₃S₂
• SMILES: C1CCC2=C(C1)C3=C(S2)N=C(N(C3=O)C4=CC=C(C=C4)Cl)SCC(=O)NNC(=O)NC5=CC(=C(C=C5)Cl)C(F)(F)F
• Target: Others,VEGFR,Raf,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163409143