VEGFR-2/AKT-IN-2 (Compound 5) is a dual inhibitor targeting VEGFR-2 and AKT signaling, demonstrating potent anti-proliferative activity in human liver cancer cell models. It induces apoptosis via caspase-3 activation and Bcl-2/BAX modulation and arrests the cell cycle in S-phase, supporting its investigation in oncology research for hepatocellular carcinoma.