Vebicorvir

SKU: orb1218479

Description

Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

Key Properties

• CAS Number: 2090064-66-5
• MW: 467.44
• Purity: >98% (HPLC)
• Formula: C₁₉H₁₂F₃N₃O₄S₂
• SMILES: O=C(c(cc1)cc(NC(c2c3cccc2)=O)c1S3(=O)=O)NCc1cnc(C(F)(F)F)s1
• Target: HBV
• Solubility: In Vitro: DMSO : 100 mg/mL (213.93 mM)

Bioactivity

• In Vivo:
  After i. v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively.
• In Vitro:
  Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68 μM, 4.95 μM, and 7.30 μM, respectively. Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ABI-H0731

Quick Database Links

Gene Symbol

HBV