VBY-825

SKU: orb1308961

Description

VBY-825 is a potent and reversible inhibitor targeting cathepsins B, L, S, and V. It is a valuable research tool for studying protease function in cancer, autoimmune disorders, and bone resorption in both cellular and animal models.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 1310340-58-9
• MW: 535.55
• Purity: 99.91% (May vary between batches)
• Formula: C₂₃H₂₉F₄N₃O₅S
• SMILES: [C@@H](N[C@H](C(N[C@H](C(C(NC1CC1)=O)=O)CC)=O)CS(CC2CC2)(=O)=O)([C@](F)(F)F)C3=CC=C(F)C=C3
• Target: Cysteine Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.47 mM);DMSO:125 mg/mL (233.4 mM)

Bioactivity

• In Vitro:
  VBY-825 is a potent assayed cathepsins inhibitor and its potency against at least one cathepsin, cathepsin S, extends across species relevant for pharmacology studies, specifically mouse. 10 mg/kg/day dose of VBY-825 achieves a trough plasma concentration >200nM, which is well above that required for full inhibition of the intracellular activity of cathepsins B, F, K, L, S and V in both mouse and human cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CysteineProtease, Cysteine Protease, Cathepsin, inhibit, Inhibitor, VBY 825, VBY825, VBY-825

Compound Identifiers

PubChem CID

70945511