Vatalanib free base

SKU: orb1307623

Description

Vatalanib is a potent and selective small molecule inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2/KDR), with a reported IC50 of 37 nM. It is widely used in preclinical research to study angiogenesis, showing efficacy in both in vitro cellular assays and in vivo tumor models.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 212141-54-3
• MW: 346.813
• Purity: 99.52% (May vary between batches)
• Formula: C₂₀H₁₅ClN₄
• SMILES: ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C3=CC=CC=C23)C=C1
• Target: VEGFR
• Solubility: DMSO:122 mg/mL (351.78 mM)

Bioactivity

• Target IC50:
  VEGFR2:37 nM (IC50)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CGP-79787, CGP79787, CGP 79787, Inhibitor, inhibit, VEGFR2, VEGFR, Vascular endothelial growth factor receptor, Vatalanib, Vatalanib free base, PTK 787, PTK/ZK, PTK787, PTK-787, ZK-222584, ZK 222584, ZK222584

Compound Identifiers

PubChem CID

151194