Varespladib methyl

SKU: orb1307624

Description

Varespladib methyl (LY333013) is an orally bioavailable prodrug of the selective secretory phospholipase A2 (sPLA2) inhibitor Varespladib. It has been utilized in research to investigate sPLA2's role in inflammatory diseases and envenomation, showing activity in both in vitro assays and in vivo animal models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 172733-08-3
• MW: 394.42
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₂₂N₂O₅
• SMILES: C(C(N)=O)(=O)C=1C=2C(N(CC3=CC=CC=C3)C1CC)=CC=CC2OCC(OC)=O
• Target: Phospholipase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (12.68 mM);DMSO:95 mg/mL (240.86 mM)

Bioactivity

• In Vitro:
  Varespladib methyl display high-level secretory PLA2 inhibition at nanomolar and picomolar concentrations against 28 medically important snake venoms from six continents .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Phospholipase, phospholipase A2 (PLA2), PLA2, Varespladib methyl, LY 333013, LY333013, LY-333013, inhibit, Inhibitor, A002, A-002, A 002

Compound Identifiers

PubChem CID

9886917