Valinomycin

SKU: orb1710768

Description

Valinomycin is a potassium ionophore and cyclic depsipeptide antibiotic. It is widely used in research to study mitochondrial membrane potential and mitophagy, as it activates PINK1 and induces Parkin phosphorylation at Ser65 in both cellular and biochemical assays.

Research Area

Cell Biology, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 2001-95-8
• MW: 1111.35
• Purity: >98%
• Formula: C₅₄H₉₀N₆O₁₈
• SMILES: CC(C)[C@@H]1NC(=O)[C@@H](C)OC(=O)[C@H](NC(=O)[C@@H](OC(=O)[C@@H](NC(=O)[C@@H](C)OC(=O)[C@H](NC(=O)[C@@H](OC(=O)[C@@H](NC(=O)[C@@H](C)OC(=O)[C@H](NC(=O)[C@@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
• Target: Ionophore
• Solubility: Soluble in DMSO (up to 10 mg/ml).

Bioactivity

• In Vivo:
  Valinomycin is irritating in contact with eyes and skin. Inhalation of Valinomycin can cause respiratory disturbances and even loss of consciousness. The median lethal dose (LD50) of Valinomycin in mice and rabbits was 2.5 mg/kg and 5 mg/kg, respectively. Valinomycin also has various chronic effects, including central and peripheral nervous system damage, eye damage, lens damage, and corneal damage .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PTEN-induced kinase 1 (PINK1), Valinomycin, Inhibitor, NSC122023, NSC-122023, inhibit, NSC 122023, Antibiotic, Apoptosis, Autophagy, Bacterial

Compound Identifiers

PubChem CID

155859174