Valganciclovir hydrochloride

SKU: orb1308294

Description

Valganciclovir HCl is the hydrochloride salt of the ganciclovir prodrug, a deoxyguanosine analog. Upon cellular phosphorylation, it inhibits viral DNA polymerase, halting replication. It is widely used in antiviral research, including in vitro assays and in vivo models for cytomegalovirus and herpesvirus infections.

Research Area

Immunology & Inflammation, Infectious Disease & Virology

Key Properties

• CAS Number: 175865-59-5
• MW: 390.82
• Purity: 99.04%
• Formula: C₁₄H₂₃ClN₆O₅
• SMILES: Cl.CC(C)[C@H](N)C(=O)OCC(CO)OCn1cnc2c1[nH]c(N)nc2=O
• Target: Antiviral,Virus Protease
• Solubility: DMSO:45 mg/mL (115.14 mM);H2O:127.94 mM;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.12 mM)

Bioactivity

• In Vivo:
  In cells infected with Cytomegalovirus (CMV), Valganciclovir is initially phosphorylated by viral protein kinase to its monophosphate form, then further phosphorylated by cellular kinases to produce its triphosphate form. This triphosphate is slowly metabolized within the cell. The phosphorylation process is dependent on viral kinase and preferentially occurs in virus-infected cells. Ganciclovir's antiviral activity is due to the triphosphate form of ganciclovir, which inhibits viral DNA synthesis. The ganciclovir triphosphate gets incorporated into the DNA, replacing many adenine bases, and hindering DNA synthesis as diester bonds take longer to form, thus diminishing the chain's stability.
• In Vitro:
  Valganciclovir is efficiently absorbed through the gastrointestinal tract, with its bioavailability approximately 60% when taken orally after meals. Upon administration, both intestinal and hepatic esterases concurrently hydrolyze the two enantiomers of ganciclovir, inhibiting the replication of human cytomegalovirus.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Valganciclovir, Valganciclovir HCl, Valganciclovir hydrochloride, Valganciclovir Hydrochloride, Valcyt, Valcyte, antiviral, Cytomegalovirus, CMV, inhibit, Inhibitor

Compound Identifiers

PubChem CID

135413534