Valdecoxib

SKU: orb1310822

Description

Valdecoxib (SC 65872) is a selective COX-2 inhibitor NSAID used in research models of inflammation and pain, such as osteoarthritis and rheumatoid arthritis. It is extensively utilized in both in vitro enzymatic assays and in vivo studies to investigate cyclooxygenase-2 pharmacology and inflammatory pathways.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 181695-72-7
• MW: 314.36
• Purity: 99.89% (May vary between batches)
• Formula: C₁₆H₁₄N₂O₃S
• SMILES: CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(S(N)(=O)=O)C=C3
• Target: COX,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.36 mM);DMSO:60 mg/mL (190.86 mM)

Bioactivity

• Target IC50:
  COX-2:5 nM|COX-1:140 μM
• In Vivo:
  Valdecoxib inhibits the production of PGE2 in plasma induced by lipopolysaccharides (IC50: 0.89 μM) and suppresses the generation of TxB2 in plasma (IC50: 25.4 μM). It binds to COX-2 with a Ka of 1.1×10^5 M/s and exhibits a strong overall saturable binding affinity to COX-2 of 2.6 nM. After 15 minutes (DP15), valdecoxib has a solubility percentage of 10.5%, while its hydrophilic derivatives (VALD-βCd, VALD-HPβCd, and VALD-SBE7βCd complexes) display significantly increased solubility percentages of 50%, 91%, and 93%, respectively.
• In Vitro:
  Valdecoxib demonstrates significant efficacy in acute and chronic inflammation models in rats, with ED50 values of 0.06 mg/kg for carrageenan air-pouch inflammation, 5.9 mg/kg for paw edema, and 0.03 mg/kg for nonspecific arthritis. When administered alone, valdecoxib shows slow absorption in vivo, achieving a maximum inhibition of 16% in edema at 3 hours post-administration. In contrast, the valdecoxib complexes VALD-βCd and VALD-SBE7βCd exhibit high absorption rates, suppressing over 50% of edema within 1 hour, and achieving a maximum inhibition of 66% at 3 hours. Orally administered valdecoxib inhibits carrageenan-induced rat paw edema with an ED50 value of 10.2 mg/kg. In a rat model of nonspecific arthritis, oral valdecoxib shows chronic anti-inflammatory activity, with an ED50 of 0.032 mg/kg/day. Valdecoxib also inhibits prostaglandin production at the inflammation site in rats with carrageenan air-pouch inflammation when administered orally, with an ED50 value of 0.02 mg/kg.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX, Cyclooxygenase, COX-2, inhibit, Inhibitor, SC65872, SC-65872, SC 65872, Valdecoxib

Compound Identifiers

PubChem CID

119607