Val-Ala-PAB-MMAE

• Catalog Number: orb2279056
• Category: Small Molecules
• Description: Val-Ala-PAB-MMAE is a drug-linker conjugate for antibody-drug conjugates (ADCs), composed of the Val-Ala-PAB cleavable linker and MMAE, a potent microtubule inhibitor. It is designed to be cleaved by Cathepsin B within cancer cells, releasing MMAE to inhibit tubulin polymerization and induce apoptosis. This mechanism reduces toxicity to normal tissues while enhancing antitumor activity.
• Target: Drug-Linker Conjugates for ADC,Microtubule Associated
• Purity: 99.02%
• MW: 1037.33
• CAS Number: 1912408-92-4
• Formula: C₅₅H₈₈N₈O₁₁
• SMILES: [C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@@H](N(C(OCC3=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)C)=O)C=C3)=O)C)C(C)C)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]
• Storage: -20°C
• Research Area: Signal Transduction
• Note: For research use only