VAF347

SKU: orb1308965

Description

VAF347 is a potent, cell-permeable aryl hydrocarbon receptor (AhR) agonist. Its anti-inflammatory properties make it a valuable research tool for studying AhR signaling in immunology and inflammation, applicable in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 574759-62-9
• MW: 349.74
• Purity: 99.82% (May vary between batches)
• Formula: C₁₇H₁₁ClF₃N₃
• SMILES: FC(F)(F)c1ccc(Nc2nccc(n2)-c2cccc(Cl)c2)cc1
• Target: Aryl Hydrocarbon Receptor
• Solubility: DMSO:17.85 mg/mL (51.04 mM);10% DMSO+90% Corn Oil:1.5 mg/mL (4.29 mM)

Bioactivity

• In Vivo:
  AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo.
• In Vitro:
  In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn. VAF347 enhances retinoic acid-induced cell cycle arrest.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VAF 347, VAF347, VAF-347, Inhibitor, inhibit, ArylHydrocarbonReceptor, aryl hydrocarbon receptor, Aryl Hydrocarbon Receptor, Aryl hydrocarbon receptor, AhR

Compound Identifiers

PubChem CID

10172275