V9302

SKU: orb1221048

Description

V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).

Key Properties

• CAS Number: 1855871-76-9
• MW: 538.69
• Purity: >98% (HPLC)
• Formula: C₃₄H₃₈N₂O₄
• SMILES: Cc1cccc(COc2ccccc2CN(CC[C@H](N)C(O)=O)Cc2ccccc2OCc2cccc(C)c2)c1
• Target: ASCT2
• Solubility: DMSO: 100 mg/mL (185.64 mM);Water: Insoluble

Bioactivity

• In Vivo:
  V-9302 (75 mg/kg; i.p.; daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models. The combination ofCB-839 and V-9302 (30 mg/kg; i.p.; SNU398 and MHCC97H cells were grown as tumor xenografts in BALB/c nude mice; for 20 or 15 d, respectively) elicits a strong growth inhibition in both SNU398 and MHCC97H xenograft models, while single-drug treatment showed modest anti-tumor effects. V-9302 (50 mg/kg; i.p.; daily for 5 days) displays markedly reduced tumor growth. Animal model: 6-week old, female athymic nude mice (bearing HCT-116 (KRAS G13D) or HT29 (BRAF V600E) cell-line). Dosage: 75 mg/kg. Administration: Intraperitoneally; daily fo 21 days. Result: Prevented tumor growth.
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• In Vitro:
  V-9302 inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide. Pharmacological blockade of ASCT2 with V-9302 results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

V 9302 | V-9302

Quick Database Links

Gene Symbol

ASCT2