USP8-IN-3

SKU: orb2900612

Description

USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively.

Key Properties

• CAS Number: 2477651-10-6
• MW: 425.43
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₈F₃N₅O₂S
• SMILES: C(F)(F)(F)C1=NC(=CC=C1)N2CCC(NC(NC3=CC=C(N(=O)=O)C=C3)=S)CC2
• Target: DUB
• Solubility: In Vitro: DMSO : 100 mg/mL (235.06 mM; Ultrasonic )

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: /. Concentration: 6.25 μM, 12.5 μM, 25 μM, 50 μM, and 100 μM Incubation time: 15 min; added Di-Ub substrate for another 1 h. Result: Decreased the cleaved diubiquitin level.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB