USP8-IN-1

SKU: orb1689809

Description

USP8-IN-1 is a small molecule inhibitor of the deubiquitinase USP8, exhibiting an IC50 of 1.9 μM. It demonstrates anti-proliferative activity in cellular assays, such as in H1975 lung cancer cells with a GI50 of 82.04 μM. This compound is a useful research tool for studying USP8's role in oncology and EGFR signaling pathways.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2477650-96-5
• MW: 387.46
• Purity: 99.07% (May vary between batches)
• Formula: C₁₈H₂₁N₅O₃S
• SMILES: COc1ccc(N2CCN(CC2)C(=S)Nc2ccc(cc2)[N+]([O-])=O)c(N)c1
• Target: DUB
• Solubility: DMSO:112.5 mg/mL (290.35 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (10.32 mM)

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP8, USP8-IN-1, USP8inhibitor

Compound Identifiers

PubChem CID

163408888