USP7-IN-4

SKU: orb1739660

Description

USP7-IN-4 (ALM4) is a potent and selective non-competitive USP7 inhibitor with a 6 nM IC50. It stabilizes p53 and induces p21, leading to anti-proliferative effects in cancer cell lines such as RS4;11 leukemia cells (EC50 = 2.0 nM). This compound is a valuable chemical probe for studying the USP7-MDM2-p53 pathway in oncology research.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2196243-57-7
• MW: 514.62
• Purity: 98.27% (May vary between batches)
• Formula: C₂₉H₃₄N₆O₃
• SMILES: CN1C(=C2C(C(=O)N(CC3(O)CCN(C(C[C@@H](C)C4=CC=CC=C4)=O)CC3)C=N2)=N1)C5=CC=C(CN)C=C5
• Target: MDM-2/p53,p53,DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AD-04, AMP 423., AMP-423, USP7 inhibitor ALM4, USP7-IN-2, USP7-IN-4

Compound Identifiers

PubChem CID

131750078