USP7-IN-1

SKU: orb1308970

Description

USP7-IN-1 is a selective, reversible inhibitor of ubiquitin-specific protease 7 (USP7) with a reported IC50 of 77 µM. This compound is a valuable research tool for investigating USP7's role in oncology and neurodegenerative disease pathways in cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1381291-36-6
• MW: 425.91
• Purity: 99.82% (May vary between batches)
• Formula: C₂₃H₂₄ClN₃O₃
• SMILES: OC1(Cn2cnc3cc(Cl)ccc3c2=O)CCN(CC1)C(=O)CCc1ccccc1
• Target: DUB
• Solubility: DMSO:55 mg/mL (129.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.7 mM)

Bioactivity

• Target IC50:
  USP7:77 μM
• In Vitro:
  USP7-IN-1 is a selective and reversible USP7 inhibitor(IC50 of 77 μM). USP7-IN-1 inhibits the proliferation of HCT116 cells(GI50 of 67 μM).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Deubiquitinase, DUBs, USP7, USP7 IN 1, USP7IN1, USP-7-IN-1, USP7-IN-1

Compound Identifiers

PubChem CID

71278663