USP7-797

SKU: orb1744337

Description

USP7-797 is a potent, selective, and orally active non-covalent USP7 inhibitor with an IC50 of 0.44 nM. It disrupts the USP7-ubiquitin interaction, demonstrating anti-tumor efficacy in vitro and in vivo by inducing apoptosis and suppressing growth in both wild-type and mutant p53 cancer cell lines.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2413944-70-2
• MW: 510.05
• Purity: 95.90% (May vary between batches)
• Formula: C₂₇H₂₈ClN₃O₃S
• SMILES: CC1(C)C2C1C(=O)N(CC=3SC=4C(C3)=NC=CC4C5=C(C[C@@H]6CNCCO6)C(C)=CC(Cl)=C5)C2=O
• Target: DUB
• Solubility: DMSO:60 mg/mL (117.64 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (6.47 mM)

Bioactivity

• In Vitro:
  Methods: USP7-797 (0-1 μM) was used to treat p53 wild-type hematological cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 wild-type hematological cancer cell lines, with CC50 values ​​of 0.2, 0.2, 0.4, and 0.1 μM for M07e, OCI-AML5, MOLM13, and MM.IS, respectively. Methods: USP7-797 (0-25 μM) was used to treat p53 mutant cancer cell lines, and cell viability was determined. Results: USP7-797 was cytotoxic to p53 mutant cancer cell lines, with CC50 values ​​of 0.5, 0.2, and 0.2 μM for H526, LA-N-2, and SK-N-DZ, respectively. Methods: USP7-797 (0-2 μM) was used to treat p53 wild-type neuroblastoma cell lines and cell viability was measured. Results: USP7-797 was cytotoxic to p53 wild-type neuroblastoma cell lines, with CC50 values ​​of 1.9, 0.6, and 0.5 μM for SH-SY5Y, CHP-134, and NB-1, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP7-IN-7, USP7797, USP 7-797

Compound Identifiers

PubChem CID

146445055