USP30 inhibitor 11

SKU: orb1708277

Description

USP30-IN-11 is a potent and selective inhibitor of the deubiquitinase USP30, exhibiting an IC50 of 0.01 µM. It has been utilized in research models to investigate its role in mitophagy, with applications in studying Parkinson's disease, cancer biology, and mitochondrial dysfunction in both cellular and animal studies.

Research Area

Cell Biology, Molecular Biology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 2067332-64-1
• MW: 368.41
• Purity: 96.31% (May vary between batches)
• Formula: C₁₇H₁₆N₆O₂S
• SMILES: COc1ccc(nc1C#N)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N
• Target: DUB
• Solubility: DMSO:20 mg/mL (54.29 mM)

Bioactivity

• Target IC50:
  USP30:0.01 µΜ
• In Vitro:
  In the mitochondrial outer membrane, USP30 is a 517 amino acid protein found. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins.USP30 inhibitor 11 inhibits USP30 biochemical activity with an IC50 of 0.01 µΜ in a USP30 biochemical IC50 assay (0.01-30 µΜ; λEx=540 nm; λEm=590 nm) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP30, USP30 inhibitor 11, USP-30 inhibitor 11, USP30-IN-11

Compound Identifiers

PubChem CID

124197552