USP30-IN-20

SKU: orb3173277

Description

USP30-IN-20 is an orally active USP30 inhibitor with a Kd of 1.61 μM and an IC50 of 12.8 μM. It induces ferroptosis by promoting the ubiquitination-mediated degradation of GPX4. This compound inhibits the proliferation, migration, and invasion of prostate cancer cells and induces G0/G1 phase arrest while increasing ROS levels. In a mouse xenograft model with PC3 cells, USP30-IN-20 demonstrates significant antitumor activity. It is applicable for advanced prostate cancer research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology, Protein Biochemistry

Key Properties

• Target: Ferroptosis,Glutathione Peroxidase,ROS,DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis,Glutathione Peroxidase,ROS,DUB