USP28-IN-4

SKU: orb1982613

Description

USP28-IN-4 is a potent and selective USP28 inhibitor (IC50 = 0.04 µM) that also targets several other deubiquitinases. It demonstrates anticancer activity in vitro by promoting c-Myc degradation via the proteasome, leading to cytotoxicity in colorectal and lung squamous carcinoma cell lines. This compound is a valuable chemical probe for studying USP28 biology and oncogenic pathways in cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2931509-15-6
• MW: 461.36
• Purity: 98.48% (May vary between batches)
• Formula: C₂₂H₁₈Cl₂N₂O₃S
• SMILES: O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C
• Target: DUB

Bioactivity

• Target IC50:
  USP28:0.04 μM
• In Vitro:
  USP28-IN-4 (12.5 μM, 15 μM; 3 days) induces cytotoxicity in human colorectal cancer and lung squamous cell carcinoma cells and significantly enhances the sensitivity of colorectal cancer cells to regorafenib.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP2, USP28, USP7, USP9x, USP8

Compound Identifiers

PubChem CID

168355498