USP28-IN-3

SKU: orb1982614

Description

USP28-IN-3 is a potent and selective USP28 inhibitor (IC50 = 0.1 µM) with additional activity against several other deubiquitinases. It demonstrates anticancer effects in vitro, notably in colorectal and lung squamous carcinoma cells, by promoting c-Myc degradation via the ubiquitin-proteasome pathway.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2931509-14-5
• MW: 475.39
• Purity: 99.85% (May vary between batches)
• Formula: C₂₃H₂₀Cl₂N₂O₃S
• SMILES: O=C(NC1=CC=C(Cl)C(=C1)C=2C=CC3=C(C2)CCNC3)C4=CC=C(C=C4Cl)S(=O)(=O)C
• Target: DUB

Bioactivity

• Target IC50:
  USP28:0.1 μM
• In Vitro:
  In human colorectal cancer cells HCT116 and Ls174T, USP28-IN-3 (20 μM-60 μM; 24 hours) dose-dependently down-regulated the cellular level of c-Myc.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP7, USP8, USP28, USP9x, USP2

Compound Identifiers

PubChem CID

168355497