USP15-IN-1

SKU: orb1688461

Description

USP15-IN-1 is a potent and selective deubiquitinase USP15 inhibitor (IC50 = 3.76 µM) with demonstrated antiproliferative effects in non-small cell lung cancer and leukemia cell models. It serves as a key research tool for investigating the USP15/cGAS DNA-sensing pathway in innate immunity and oncology research.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2260826-16-0
• MW: 377.44
• Purity: 99.35% (May vary between batches)
• Formula: C₂₂H₂₃N₃O₃
• SMILES: OCCNC(=O)c1ccc2[nH]c3CN(CCc3c2c1)C(=O)Cc1ccccc1
• Target: DUB
• Solubility: DMSO:90 mg/mL (238.45 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (2.65 mM)

Bioactivity

• Target IC50:
  USP15:3.76 μM
• In Vitro:
  USP15-IN-1 (0.001-5 μM; 48 h) demonstrates significant inhibitory effects on the proliferation of non-small cell lung carcinoma and leukemia cells, as reported in.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

USP15

Compound Identifiers

PubChem CID

165412585