USP11-IN-1

SKU: orb3174635

Description

USP11-IN-1 (Compound 26) is a selective inhibitor of ubiquitin-specific protease 11 (USP11) with an IC50 value of 10.9 μM. It displays IC50 values of 18.1 μM for USP4 and greater than 500 μM for USP15, with a selectivity index (SI) of 1.7 and more than 100, respectively. USP11-IN-1 demonstrates significant antiproliferative activity against PEO4 and MDA-MB-231 cells, with IC50 values of 0.47 μM and 6.5 μM, while exhibiting lower cytotoxicity towards MRC-5 cells (IC50 greater than 10 μM). This compound is applicable in the study of USP11-related malignancies.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• Target: DUB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DUB