USP1-IN-5

SKU: orb2277676

Description

USP1-IN-5 (compound 10) is a potent small molecule inhibitor of the deubiquitinase USP1, demonstrating IC50 values below 50 nM in both enzymatic and cellular (MDA-MB-436) assays. This inhibitor is a valuable research tool for studying DNA damage repair pathways and has been utilized in vitro to explore synthetic lethality in BRCA1-deficient cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 2925547-94-8
• MW: 532.52
• Formula: C₂₇H₂₃F₃N₈O
• SMILES: CN1C(C23C4C5C2C6C3C4C56CN7C=8C(C=N7)=CN=C(N8)C=9C(=NC=NC9OC)C%10CC%10)=NC(C(F)(F)F)=C1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168510617