Uric acid sodium

SKU: orb1741466

Description

Uric acid sodium is a potent antioxidant used in research to study oxidative stress, hypertension models, and pathologies like gout and kidney stones. It scavenges reactive oxygen species and inhibits lipid peroxidation in both in vitro and in vivo experimental systems.

Research Area

Immunology & Inflammation, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1198-77-2
• MW: 190.09
• Purity: 99.92% (May vary between batches)
• Formula: C₅H₃N₄NaO₃
• SMILES: [NaH].O=c1[nH]c2[nH]c(=O)[nH]c(=O)c2[nH]1
• Target: Reactive Oxygen Species
• Solubility: DMSO:2.8 mg/mL (14.73 mM)

Bioactivity

• In Vivo:
  Oral treatment of uric acid sodium at a dosage of 250 mg/kg has a beneficial effect on indomethacin-induced enteropathy. It ameliorates the enteropathy caused by indomethacin. Oral treatment of uric acid sodium leads to a reduction in ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy .
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• In Vitro:
  Uric acid, when administered at a concentration of 400 μM for 48 hours, offers protection to Caco-2 cells by preventing indomethacin-induced lipid peroxidation . Furthermore, co-treatment of cells with indomethacin and uric acid sodium (200 μM indomethacin plus 400 μM uric acid; 24 hours) significantly reduces reactive oxygen species (ROS) levels compared to cells treated with indomethacin alone. Additionally, cell viability in Caco-2 cells exposed to both indomethacin and uric acid sodium (200 μM indomethacin plus 400 μM uric acid; 24 hours) is higher compared to cells treated solely with indomethacin. The protective effect of uric acid sodium on indomethacin-induced changes in intestinal cells is attributed to its antioxidant activity .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reactive Oxygen Species, ReactiveOxygenSpecies, Uric acid sodium, Monosodium urate

Compound Identifiers

PubChem CID

132984050