Uracil

SKU: orb1310972

Description

Uracil is a natural pyrimidine nucleobase in RNA, where it pairs with adenine. It functions as an allosteric regulator and coenzyme in biochemical reactions and is a key precursor in synthesizing enzymes vital for cellular processes. This compound is widely used in molecular biology research, including studies on RNA metabolism, nucleotide biosynthesis, and in vitro transcription assays.

Research Area

Metabolism Research

Key Properties

• CAS Number: 66-22-8
• MW: 112.09
• Purity: 99.97% (May vary between batches)
• Formula: C₄H₄N₂O₂
• SMILES: O=C1NC=CC(=O)N1
• Target: Endogenous Metabolite
• Solubility: DMSO:18.33 mg/mL (163.53 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (17.84 mM);Ethanol:21 mg/mL (187.35 mM)

Bioactivity

• In Vivo:
  Uracil serves both as a pharmaceutical agent and as a vehicle for drug delivery. In humans and plants, uracil functions is a conformational regulator and coenzyme in various reactions. It also plays a role in the biosynthesis of polysaccharides and the transportation of aldoses. Uracil reacts with fluorine to form 5-fluorouracil, which inhibits RNA polymerase, obstructing RNA synthesis and consequently suppressing the growth of cancer cells. Within the body, uracil binds with ribose and phosphate, aiding insynthesizing enzymes essential for numerous cellular functions.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Inhibitor, inhibit, RNA, Uracil

Compound Identifiers

PubChem CID

1174