Uprosertib

SKU: orb1223448

Description

Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Key Properties

• CAS Number: 1047634-65-0
• MW: 429.25
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆Cl₂F₂N₄O₂
• SMILES: Cn1c(c(cn1)Cl)c1c(oc(c1)C(=O)N[C@@H](Cc1cc(c(cc1)F)F)CN)Cl
• Target: Akt1| Akt2| Akt3
• Solubility: DMSO : ≥ 150 mg/mL 349.45 mM H2O : < 0.1 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GSK2141795, GSK 795, Uprosertib

Quick Database Links

Gene Symbol

Akt1| Akt2| Akt3