Uplarafenib

SKU: orb1686710

Description

Uplarafenib (B-Raf IN 10) is a potent and selective BRAF inhibitor with an IC50 of 50-100 nM. It demonstrates antitumor activity by inhibiting proliferation in vitro and has shown efficacy in vivo models of solid tumors, such as melanoma, supporting its use in oncology research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1425485-87-5
• MW: 494.49
• Purity: 99.85% (May vary between batches)
• Formula: C₂₂H₂₁F₃N₄O₄S
• SMILES: CCCS(=O)(=O)Nc1cc(F)c(F)c(C(=O)c2ccc3ncc(nc3c2)N2CCOCC2)c1F
• Target: Raf
• Solubility: DMSO:90 mg/mL (182.01 mM)

Bioactivity

• In Vitro:
  Uplarafenib (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E . Uplarafenib shows an IC 50 between 50 and 100 nM against BRAF, and less than 50 nM against BRAF V600E. Uplarafenib (72 h) inhibits A375 and SK-MEL-28 cell growth but not CHL-1 and SK-MEL-31 cells . Cell Viability Assay. Cell Line: A375, SK-MEL-28, SK-MEL-31, and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

B-Raf, B-Raf IN 10, Uplarafenib

Compound Identifiers

PubChem CID

71506198