Upamostat

SKU: orb1308973

Description

Upamostat is a small molecule serine protease inhibitor that selectively targets urokinase plasminogen activator (uPA). It is used in research to study tumor invasion, metastasis, and angiogenesis in both in vitro cell-based assays and in vivo cancer models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 590368-25-5
• MW: 629.81
• Purity: 98.80% (May vary between batches)
• Formula: C₃₂H₄₇N₅O₆S
• SMILES: CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(=N)NO)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C
• Target: Serine Protease,PAI-1,Serine/threonin kinase
• Solubility: 10% DMSO+90% Corn Oil:3.3 mg/mL (5.24 mM);DMSO:250 mg/mL (396.95 mM)

Bioactivity

• In Vitro:
  Upamostat is an inhibitor of urokinase plasminogen activator (uPA). Upamostat is the oral prodrug of the active metabolite WX-UK1, a novel inhibitor of uPA . Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, and plays a major role in tumor invasion and metastasis. Upamostat is the orally available amidoxime- (i.e. hydroxyamidine-) prodrug of the pharmacologically active form, WX-UK1 .

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, PAI1, PAI-1, Inhibitor, WX 671, WX671, WX-671, Ser/Thr Protease, Serine endopeptidases, Serine kinase, Serine Protease, Serine protease, Serinekinase, Threonine proteases, threonin kinase, SerineProtease, threoninkinase, Serine proteases, Plasminogen activator inhibitor-1, Upamostat

Compound Identifiers

PubChem CID

90937527