UNC9426

SKU: orb3028451

Description

UNC9426 is an orally active, potent and selective TYRO3 inhibitor with an IC50 of 2.1 nM. It reduces platelet aggregation without prolonging bleeding time and blocks TYRO3-dependent functions in tumour cells and macrophages, making it suitable for studying thrombosis and platelet aggregation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3051784-94-9
• MW: 632.642
• Purity: 98.05% (May vary between batches)
• Formula: C₃₂H₃₄F₆N₆O
• SMILES: N(C=1N=C2C(C(=CN2[C@H]3CC[C@H](O)CC3)C4=CC=C(CN5CCN(C)CC5)C=C4)=CN1)C6=CC(C(F)(F)F)=CC(C(F)(F)F)=C6
• Target: Platelet aggregation,TAM Receptor
• Solubility: DMSO:15 mg/mL (23.71 mM)

Bioactivity

• Target IC50:
  Tyro3:2.1 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SEA-CD40, SEA CD40

Quick Database Links

Gene Symbol

Platelet aggregation,TAM Receptor