UNC2250

SKU: orb1226187

Description

UNC2250 is a potent and selective Mer inhibitor with IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

Key Properties

• CAS Number: 1493694-70-4
• MW: 440.58
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₆N₆O₂
• SMILES: O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1
• Target: TAM Receptor
• Solubility: DMSO: 2 mg/mL warmed (4.53 mM)

Bioactivity

• In Vitro:
  UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM. UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer. UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines. Western blot analysis. Cell line: 697 B-ALL cells. Concentration: 5, 10, 20, 50, 100, 250, 500 nM. Incubation time: 1 hour. Result: Inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UNC2250, UNC-2250, UNC 2250

Quick Database Links

Gene Symbol

TAM Receptor